Chronic low back pain is a common analgesic model because of its high prevalence and clinical significance. Lotus Clinical Research has experience and proficiency in both neuropathic and non-neuropathic low back pain studies, and we have enrolled both opioid experienced and opioid naïve subjects into our clinical trials.
Enriched Enrollment Randomized Withdrawal (EERW) designs are common in chronic pain investigations because they confer greater assay sensitivity. Appropriate implementation experiments with EERW designs can have logistical challenges. Lotus Clinical Research has the requisite knowledge and experience to successfully run EERW LBP studies.
Investigations into radicular low back pain (low back pain with a neuropathic component) can be difficult to implement. Lotus Clinical Research has initiated multiple studies in which we have executed intensive investigator training to standardize the diagnosis of radicular low back pain. We have a network of sites that are experienced in quantitative sensory testing with neurologists on staff serving as either principal or sub-investigators.
Lotus Clinical Research has close relationships with imaging centers near its research unit. We have utilized both CT scans and MRI scans for various low back pain investigations. Our trained investigators can inject investigational product under fluoroscopy with retention of the video images for future use.