PRESS ROOM

June 26, 2014

Dr. Neil Singla chairs a new special interest group at the IASP

Dr. Neil Singla chairs a new special interest group at the IASP titled: Clinical Trials. The purpose of the group is to explore methodological improvements in analgesic research.

Dr. Singla will also be speaking at the Acute Pain SIG. The talk is titled: “Decreasing placebo response and false negative outcomes in analgesic clinical trials.”

We will also have a booth #314. Please swing by our booth to learn more about our CRO and Site services and how we can help you with your clinical program.

May 5, 2014

WEBINAR: Expert Review of Recently Released FDA Analgesic Draft Guidance


In February of 2014 the FDA released a draft guidance document related to the development of drugs for analgesic indications. The importance of this document cannot be over emphasized in that it speaks to the current mindset of the FDA’s Division of Anesthesia, Analgesia, and Addiction Products (DAAAP). A multitude of topics are covered in it, including specific information regarding the following:

  • The development of new molecular entities versus reformulations
  • Requisite paths to specific analgesic indications
  • Early phase requirements
  • Appropriate endpoint selection
  • Recommended strategies for administration of rescue medication
  • Data imputation guidelines
  • Acceptable patient reported outcomes etc.

April 1, 2013

Lotus to Present Scientific Poster at APS 2013

Lotus Clinical Research will be presenting a Scientific Poster at the American Pain Society’s 32nd Annual Scientific Meeting May 8-11 in New Orleans, LA entitled “A systematic review of the sensitivity of efficacy endpoints TOTPAR and SPID in acute pain”. Poster will be available on May 8th, 2013.

April 1, 2013

Dr. Neil Singla and Dr. Nathaniel Katz to chair the Clinical Trials SIG Session at APS 2013

The Clinical Trials SIG will discuss “Reducing the Risk of Failure in Analgesic Clinical Trials,” with presentations by Nathaniel Katz, MD MS, and Neil Singla, MD. Dr. Nathaniel Katz will discuss “An Evidence-Based Approach to Improving Assay Sensitivity in Clinical Trials” and Dr. Neil Singla will discuss “Applying the Principles of Improved Assay Sensitivity in Analgesic Drug Development.”

Click here for more information on the upcoming APS Meeting

July 1, 2012

Dr. Neil Singla to present at the 6th Annual Pain Therapeutics Summit in San Jose, CA

Neil Singla, MD, Founder & Chief Scientific Officer, Lotus Clinical Research, LLC will be giving a presentation entitled “Minimizing experimental error in analgesic research by reducing placebo response and variability” at the 6th Annual Pain Therapeutics Summit. Read full story

April 6, 2012

Lotus to Present Scientific Poster at APS 2012

Lotus Clinical Research will be presenting a Scientific Poster at the American Pain Society’s 31st Annual Scientific Meeting May 16-19 in Honolulu, Hawaii entitled “Decreasing the number of clinical centers involved in an analgesic trial may increase the effect size and reduce the probability of a false negative” Click here to view poster presented at APS 2012

April 6, 2012

Dr. Neil Singla and Dr. Nathaniel Katz to chair the Clinical Trials SIG Session at APS 2012

The Clinical Trials SIG will discuss “Reducing the Risk of Failure in Analgesic Clinical Trials,” with presentations by Nathaniel Katz, MD MS, and Neil Singla, MD. Dr. Nathaniel Katz will discuss “An Evidence-Based Approach to Improving Assay Sensitivity in Clinical Trials” and Dr. Neil Singla will discuss “Applying the Principles of Improved Assay Sensitivity in Analgesic Drug Development.” Click here for more information on the upcoming APS Meeting:

January 4, 2012

ProFibrix

ProFibrix US Phase II Study with FibrocapsTM Meets All Primary and Secondary Endpoints
Dr. Neil Singla, one of the Principal Investigators of the US Phase II study, said: “The combined ease of use and efficacy of Fibrocaps in spinal and vascular surgery constitute a great leap forward in hemostasis in these surgical settings…Read full story

August 25, 2011

Lotus Clinical Research, LLC

Lotus to Sponsor CHI’s Accelerating Proof-of-Concept Conference in Philadelphia, PA
Lotus Clinical Research, LLC is confirmed as a sponsor of CHI's third annual Accelerating-Proof-of-Concept: Clinical Success Driven by Science & Strategy conference. This conference will take place on October 3-5, 2011 at the Crowne Plaza Philadelphia Downtown, Philadelphia, PA... Read full story

August 10, 2011

Adolor Corporation

Adolor Corporation Announces Positive Results from Phase 2 Program in OIC
“Opioid analgesics have become a cornerstone of multimodal therapy for the management of patients who suffer with chronic non-cancer pain,” said Neil Singla, M.D., lead investigator for the Phase 2 program… Read full story

September 10, 2010

Lotus Clinical Research, LLC

Lotus Clinical Research to present Assay Sensitivity Case Study at the upcoming ACCP Conference
Lotus Clinical Research will be presenting a poster entitled “Assay Sensitivity Can Be Higher in Single-Site than Multiple-Site Acute Pain Studies: A Case Study” at the upcoming American College of Clinical Pharmacology (ACCP) Conference … Read full story

September 8, 2010

Cumberland Pharmaceuticals

IV Ibuprofen Lessens Morphine Use
“These findings are significant in that they not only confirm that Caldolor is effective in reducing both post-operative pain and morphine use, but also demonstrate that it can be safely administered prior to the induction of anesthesia,” said Neil Singla, M.D. … Read full story

August 30, 2010

Cumberland Pharmaceuticals, Inc.

Pre and Post-Operative Use of Caldolor® (Ibuprofen) Injection Significantly Reduces Pain and Opioid Use in Newly Published Study
“This gives physicians additional options for controlling the onset of post-operative pain, which can help improve patient comfort and thereby facilitate recovery” said Neil Singla, MD, Founder and Chief Scientific Officer of Lotus Clinical Research… Read full story

May 25, 2010

AcelRx Pharmaceuticals, Inc.

AcelRx Announces Positive Phase 2 Results
AcelRx Pharmaceuticals, Inc. today announced positive results from a Phase 2 clinical study evaluating the safety and efficacy of the ARX-02 Sufentanil NanoTab™ Breakthrough Pain Management System in the treatment of cancer breakthrough pain in opioid-tolerant patients. …Read full story

March 4, 2010

Cumberland Pharmaceuticals, Inc.

Key Caldolor(R) Orthopedic Data to Be Presented at American Academy of Orthopaedic Surgeons' Annual Meeting
Neil Singla, M.D., Chief Executive Officer of Lotus Clinical Research, Inc., is the principal investigator of the study and Byron Kaelin, BSHS, RN, Manager of Clinical Operations at Cumberland Pharmaceuticals Inc., is the presenting author…Read full story

November 15, 2009

The Medicines Company

Cleviprex Results Reported From Study In Patients With Intracerebral Hemorrhage
Cleviprex has proven to be safe and effective in this critical patient population requiring fast, precise blood pressure control within a target range. It is an important tool for physicians managing blood pressures in a variety of patients… Read full story

February 6, 2009

ROXRO Pharma, Inc.

Roxro Announces FDA Accepts for Review NDA for ROX-888 for the Management of Acute Moderate to Severe Pain
Dr. Neil Singla, Chief Executive Officer of Lotus Clinical Development, Inc. and lead investigator for ROXRO's second Phase 3 study said "ROX-888 could fulfill a compelling medical need for both clinicians and patients”… Read full story

December 1, 2008

PharmaExec.com

The 2008 Pipeline Report – Breakthrough NSAIDS
"This is a drug that can be easily administered in a home environment," says Neil Singla, MD, of Lotus Clinical Research in Pasadena, CA. "That's a huge advantage."… Read full story

August 1, 2008

Huntington Advocate

New Methods of reducing Pain Identified at Huntington
Surgery-related pain is being reduced at Huntington Hospital thanks to important research in pain management. Dr. Neil Singla heads an organization that is looking at the efficacy of medications targeting postsurgical pain… Read full story

May 5, 2008

Roxro Pharma Inc.

Roxro Pharma’s Phase 3 Intranasal Analgesic Data Receives Excellence Award
ROXRO PHARMA has received an Excellence and Innovation Award for the Phase 3 data of the company's novel intranasal pain reliever ROX-888, which is in development for the treatment of moderate-to-severe pain. Dr. Neil Singla was the lead author. ...Read full story

June 6, 2007

Roxro Pharma Inc.

Roxro Pharma’s Novel Intranasal Pain Reliever Effective, well tolerated in Phase 3 Study
“ROX-888 is an important breakthrough in treating pain,” said Dr. Neil Singla, Director of Clinical Research at Huntington Memorial Hospital in Los Angeles, “It is rapidly absorbed into the bloodstream, and relieves pain as fast as an intramuscular injection… Read full story

September 1, 2007

Physicians Practice

Medical Staff Snapshot – Dr. Neil Singla
A specialist in post surgical pain and nausea management, Dr. Singla has published several articles in anesthesia journals and trade magazines. He is a compassionate patient advocate who works tirelessly towards the advancement… Read full story