SCIENTIFIC PUBLICATIONS

2014

  1. JUN 2014 - Axelopran Phase 2b Study Demonstrates a Sustained Increase in Bowel Movement Frequency in Patients Regardless of Duration of Opioid-Induced Constipation
  2. MAR 2014 - A comparison of the clinical and experimental characteristics of four acute surgical pain models: Dental extraction, bunionectomy, joint replacement, and soft tissue surgery

2013

  1. OCT 2013 - TD‐1211 Phase 2B Study Demonstrates Increased Bowel Movement Frequency in patients with Opioid-Induced Constipation (OIC) Regardless of Baseline Opioid Dose: Poster presented at The European Federation of IASP Chapters (EFIC)Congress: Pain in Europe VIII held October 9-12, 2013 in Florence, Italy.
  2. OCT 2013 - Open-Label Extension of a Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study of the Safety and Analgesic Efficacy of MNK-795 Oxycodone/Acetaminophen Extended-Release (OC/APAP ER) Tablets in an Acute Pain Model: Poster presented at the 2013 Midwest Pain Society Meeting held October 25-26, 2013 in Chicago, IL.
  3. SEPT 2013 - No Evidence of Analgesic Interference or CNS Opioid Withdrawal for TD-1211 in a Phase 2b Study in Opioid-Induced Constipation (OIC):Poster presentation presented at Pain Week 2013 held September 4-7, 2013 in Las Vegas, Nevada.
  4. SEPT 2013 - TD-1211 Demonstrates a Durable Increase in Bowel Movement Frequency and Return Toward Normal Bowel Function in a 5-Week Ph2b Opioid-Induced Constipation (OIC) Study: Poster presentation presented at Pain Week 2013 held September 4-7, 2013 in Las Vegas, Nevada.
  5. SEPT 2013 - Open-Label Extension of a Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study of the Safety and Analgesic Efficacy of MNK-795 Controlled-Release Oxycodone/Acetaminophen Tablets (CR OC/APAP) in an Acute Pain Model: Poster presentation presented at Pain Week 2013 held September 4-7, 2013 in Las Vegas, Nevada.
  6. SEPT 2013 - A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study of the Safety and Analgesic Efficacy ofMNK-795 Controlled-Release Oxycodone/Acetaminophen Tablets (CR OC/APAP) in an Acute Pain Model: Oral poster presentation presented at Pain Week 2013 held September 4-7, 2013 in Las Vegas, Nevada.
  7. SEPT 2013 - A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study of the Safety and Analgesic Efficacy ofMNK-795 Controlled-Release Oxycodone/Acetaminophen Tablets (CR OC/APAP) in an Acute Pain Model: Poster presentation presented at Pain Week 2013 held September 4-7, 2013 in Las Vegas, Nevada.
  8. JUNE 2013 - TD-1211 Demonstrates Increased Bowel Movement Frequency with No Evidence of Analgesic Interference or CNS Opioid Withdrawal in a Phase 2b Study in Opioid Induced Constipation (OIC): Oral poster presentation presented at the International Conference On Opioids (ICOO) held June 9-11, 2013 in Boston, Massachusetts.
  9. MAY 2013 - TD-1211 Phase 2b Study Demonstrates Increased Bowel Movement Frequency and Constipation-Related Symptom Improvement in Patients with Opioid Induced Constipation (OIC): Poster presented at the 2013 Digestive Disease Week held May 18-21, 2013 in Orlando, Florida.
  10. MAY 2013 - TD-1211 Demonstrates Tolerability and Clinical Activity Following Multiple Treatment Administration Strategies in Patients with Opioid-Induced Constipation (OIC)
  11. MAY 2013 - TD-1211 Demonstrates a Durable Increase in Bowel Movement Frequency and Return Toward Normal Bowel Function in a 5-Week Ph2b Opioid-Induced Constipation (OIC) Study
  12. MAY 2013 - No Evidence of Analgesic Interference or CNS Opioid Withdrawal for TD-1211 in a Phase 2b Study in Opioid-Induced Constipation (OIC)
  13. MAY 2013 - A systematic review of the sensitivity of efficacy endpoints TOTPAR and SPID in acute pain
  14. APR 2013 - Pulsed Radio Frequency Energy (PRFE) fields in the treatment of post-operative pain: a randomized, double-blind, sham-controlled pivotal study in the human bunion model
  15. FEB 2013 - The Pharmacokinetic Profile of Liposome Bupivacaine Injection.

2012

  1. NOV 2012 - Novel Injectable Formulation of Diclofenac Compared with Intravenous Ketorolac and Placebo for Acute Treatment of Moderate to Severe Pain after Abdominal or Pelvic Surgery: A Double-Blind, Multicenter, Randomized, Multiple-Dose Study
  2. NOV 28, 2012 - Safety and Immunogenicity of Recombinant Human Thrombin: A Pooled Analysis of Results from 10 Clinical Trials.
  3. OCT 23, 2012 - TD-1211 Demonstrates Improvement in Bowel Movement Frequency and Bristol Stool Scores in a Phase 2b Study of Patients with Opioid-Induced Constipation
  4. OCT 23, 2012 - TD-1211 Demonstrates Improvement in Bowel Movement Frequency and Bristol Stool Scores in a Phase 2b Study of Patients with Opioid-Induced Constipation
  5. SEP 21, 2012 - Phase 2b Evaluation of TD-1211in Opioid-Induced Constipation
  6. SEP 5, 2012 - TD-1211 Demonstrates Improvement in Bowel Movement Frequency Without Impacting Analgesia in a Phase 2b Study of Patients with Opioid-Induced Constipation
  7. SEP 2012 - Plasma and Cerebrospinal Fluid Pharmacokinetic Parameters After Single-Dose Administration of Intravenous, Oral, or Rectal Acetaminophen
  8. JUN 9, 2012 - Safety and Immunogenicity of Recombinant Human Thrombin with Absorbable Gelatin Powder when Applied as a Flowable Topical Hemostat
  9. MAY 21, 2012 - CB-5945 0.25 mg Twice Daily is Associated with Significantly Increased Spontaneous Bowel Movement and Greater Proportion of Responders Compared with Placebo in Patients on Chronic Opioid Therapy for Noncancer Pain (45CL242; NCT01207427)
  10. MAY 16, 2012 - CB-5945 (Formerly ADL5945), a Potent Orally Bioavailable Peripheral Opioid Receptor Antagonist, Improves Bowel Motility With a Low Incidence and Severity of Gastrointestinal Adverse Effects in a Dose-dependent Manner; Results of 2 Phase 2 Trials in Patients with Opioid-induced Constipation
  11. MAY 16, 2012 - Decreasing the number of clinical centers involved in an analgesic trial may increase effect size and reduce the probability of a false negative

2011

  1. NOV 17, 2011 - Plasma and Cerebrospinal Fluid Pharmacokinetic Parameters after Single-Dose Administration of Intravenous,Oral or Rectal Acetaminophen.
  2. OCT 28, 2011 - TD-1211 Demonstrates Constipation-relieving Effects, Including Decrease in Rescue Laxative Use, in Patients with Opioid-Induced Constipation.
  3. OCT 16, 2011 - DepoFoam® Bupivacaine (DB; EXPAREL™; Bupivacaine Extended Release Multivesicular Liposome Injection) Exhibits Pharmacokinetic Properties Consistent with Sustained Release Characteristics.
  4. OCT 15, 2011 - EXPARELTM, a Bupivacaine Extended Release Multivesicular Liposomal Formulation, ExhibitsPharmacokinetic Properties Consistent with Sustained Release Characteristics:
  5. SEPT 20, 2011 - Plasma and Cerebrospinal Fluid Pharmacokinetic Parameters after Single-Dose Administration of Intravenous,Oral or Rectal Acetaminophen.
  6. SEP 7, 2011 - TD-1211 Demonstrates Peripheral Selectivity and Constipation-Relieving Effects in Patients with Opioid-Induced Constipation.
  7. MAY 21, 2011 - A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study to Evaluate the Clinical Efficacy, Safety, and Tolerability of ARX-03 Sublingual Sufentanil/Triazolam15 mcg/200 mcg NanoTab® in Patients Undergoing an Elective Abdominal Liposuction Procedure
  8. May 19, 2011 - Oxycodone HCl/niacin in relieving moderate-to-severe postoperative pain following bunionectomy surgery: timing of analgesic response.
  9. MAR 27, 2011 - Daniels, S; Spivey, R; Singla, S; Golf, M; Clark, F. Efficacy and safety of oxycodone HCl/niacin tablets for the treatment of moderate-to-severe postoperative pain following bunionectomy surgery
  10. JAN 1, 2011 - Singla NK, Chung, F.; Lotus Clinical Research, Inc. Why no Casopitant-only arm? [Reply to letter to the editor].

2010

  1. DEC 1, 2010 - A randomized, double-blind, placebo-controlled, multicenter, repeat-dose study of two intravenous acetaminophen dosing regimens for the treatment of pain after abdominal laparoscopic surgery
  2. DEC 1, 2010 - Candiotti - Safety of Multiple-Dose Intravenous Acetaminophen in Adult Inpatients
  3. NOV 22, 2010 - Diclofenac gel and diclofenac patch. In: Raymond S. Sinatra, Jonathan S. Jahr and J. Michael Watkins-Pitchford The Essence of Analgesia and Analgesics. New York, NY: Cambridge University Press.
  4. OCT 17, 2010 - Evaluation of the Immunogenicity and Safety of Recombinant Human Thrombin After Subsequent Surgical Re-exposure
  5. OCT 16, 2010 - Use of Pregabalin for Postoperative Pain: Outcomes in 2 Trials
  6. SEPT 12, 2010 - Assay Sensitivity Can Be Higher in Single-Site Than Multiple-Site Acute Pain Studies: A Case Study
  7. AUG 1, 2010 - Intranasal ketorolac for acute postoperative pain
  8. AUG 1, 2010 - A Multi-Center, Randomized, Double-Blind Placebo-Controlled Trial of Intravenous-Ibuprofen (IV-Ibuprofen) for Treatment of Pain in Post-Operative Orthopedic Adult Patients
  9. JUL 1, 2010 - Phase II Study to Evaluate the Safety and Efficacy of the Oral Neurokinin-1 Receptor Antagonist Casopitant (GW679769) Administered with Ondansetron for the Prevention of Postoperative and Postdischarge Nausea and Vomiting in High-risk Patients
  10. JUN 12, 2010 - Efficacy and Safety of Pregabalin in the Treatment of Postoperative Pain Following Inguinal Herniorrhaphy
  11. APR 22, 2010 - A Phase 2, Multicenter, Randomized, Placebo-Controlled Study to Evaluate the Clinical Efficacy, Safety, and Tolerability of Sublingual Sufentanil NanoTab™ in Patients Undergoing Major Abdominal Surgery
  12. MAR 9, 2010 - A Clinical Trial of Intravenous Ibuprofen for Treatment of Pain in Orthopedic Surgical Patients

2009

  1. OCT 18, 2009 - Persistence of Antibodies for the Topical Hemostat Bovine Thrombin
  2. OCT 17, 2009- Rolapitant for the Prevention of Postoperative Nausea and Vomiting - A Prospective, Double-blinded, Placebo-controlled Randomized Trial
  3. OCT 14, 2009 - Epidemiology of Central Venous (CVC) and Arterial (AC) Intravenous Catheters (IVC) in Intensive care Units (ICU)
  4. SEP 12, 2009 - Use of Omiganon, A new Topical Cationic Peptide for Preventing Local Catheter Site infections (LCSI) and Catheter Colonization (CC) in Patients with Central Venous Catheters (CVC) New Antimicrobial Agents and Approaches to Monitoring their Use
  5. MAY 9, 2009 - Acurox (Oxycodone HCL/Niacin) Tablets for the Treatment of Acute, Moderate to Severe Pain Following Bunionectomy Surgery in Adult Patients
  6. APR 30, 2009- A Phase III, Multi-Center, Open-Label, Prospective, Repeated Dose, Randomized, Controlled, Multi-Day Study of the Safety of Intravenous Acetaminophen in Adult Patients:

2008

  1. DEC 6, 2008 - Favorable Immunologic Response to Recombinant Thrombin Application in Surgery Among Subjects with Pre-existing Antibodies to Bovine Thrombin
  2. OCT 18, 2008 - Clevidipine Dose Requirements in Cardiac Surgery Patients with Perioperative Hypertension
  3. JUL 1, 2008 - Treatment of Acute Postoperative Hypertension in Cardiac Surgery Patients: An Efficacy Study of Clevidipine Assessing Its Postoperative Antihypertensive Effect in Cardiac Surgery-2 (ESCAPE-2), a Randomized, Double-Blind, Placebo-Controlled Trial
  4. MAY 1, 2008 - Intranasal Ketorolac (ROX-888) for Postoperative Pain: A Phase 3, Doubleblind Randomized Study
  5. MAY 1, 2008 - A Randomized, Double-Blind, Placebo-Controlled, Multi-Center, Parallel-Group, Multiple-Dose Study of the Efficacy and Safety of Intravenous Acetaminophen over 48 Hours for the Treatment of Postoperative Pain after Gynecologic Surgery
  6. MAY 1, 2008 - A Review of the Intravenous Acetaminophen Placebo-Controlled Clinical TrialSafety Experience: A Focus on Hepatic Transaminases

2007

  1. JUN 8, 2007 - Efficacy and Tolerability of Oxymorphone Immediate Release for Acute Postoperative Pain After Abdominal Surgery: A Randomized, Double-Blind, Active- and Placebo-Controlled, Parallel-Group Trial

2005

  1. MAY 1, 2005 - Forty-eight Hours of Postoperative Pain Relief after Total Hip Arthroplasty with a Novel, Extended-Release Epidural Morphine Formulation