To determine whether pre- and postoperative administration of intravenous ibuprofen (IV-ibuprofen) can significantly decrease pain and morphine use when compared with placebo in adult orthopedic surgical patients.
This was a multi-center, randomized, double-blind placebo-controlled trial.
This study was completed at eight hospitals; six in the United States and two in South Africa.
A total of 185 adult patients undergoing elective orthopedic surgery.
Patients were randomized to receive either 800 mg IV-ibuprofen or placebo every 6 hours, with the first dose administered pre-operatively.
Additionally, all patients had access to intravenous morphine for rescue