Reducing Variability/Placebo Response
The properly educated patient can be your greatest ally in producing a positive analgesic clinical trial. A significant portion of an analgesic investigation's variability is produced secondary to cognitive gaps that the patient may have when interpreting various protocol mandated scales and questions. All pharmaceutical companies spend a large amount of time perfecting their protocol and selecting/educating quality sites so that the efficacy of their drug can be statistically demonstrated. However, an equal amount of effort is rarely placed on patient education. At Lotus, we believe this piece of the puzzle is the responsibility of the site and as such, we have developed proprietary educational materials including a patient education video and a detailed patient post-test.
Placebo Response Education
Lotus has developed a proprietary placebo response video education series designed to modulate patient expectations and dampen placebo response. Read more…
Phase 1 and Analgesic Proof-of-Concept
Lotus' patient training tools and data collection methodologies result in reduced variability and improved statistical sensitivity towards the primary efficacy endpoint. Read more…
Maximizing Effect Size
Experimental error can reduce effect size and lead to a false negative result. In this video we describe the three most common sources of experimental error in analgesic investigations. Read more…
